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Which of the following mutations have the most significant effect on protein synthesis?

a. Base pair substitutions
b. Silent mutations
c. Intron mutations
d. Frameshift mutations

Marked as best answer by Sleepy


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The frameshift mutation involves the insertion or deletion of one or more base pairs of the DNA molecule. This greatly alters the amino acid sequence, which affects protein synthesis. The base pair substitution is a type of mutation in which one base pair replaces another. Silent mutations do not change amino acids or protein synthesis. Intron mutations are part of RNA sequencing.

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