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What has been the evidence for the use of heliox during mechanical ventilation in patients with COPD exacerbations?

A. The data are inconclusive.
B. Results reveal that heliox lowers the Pplateau and reduces auto-PEEP.
C. Heliox has shown to decrease pulmonary compliance and to decrease airway resistance.
D. Evidence indicates heliox has no effect on the outcome regarding mechanically ventilated COPD patients.

Marked as best answer by Dylan

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ANS: A
A. Correct response: The evidence for the use of heliox in patients with COPD exacerbations is not robust or mature. Most of the peer-reviewed literature consists of case reports, case series, and physiologic studies in small samples of carefully selected patients. Even in the physiologic studies, a consistent response is not reported in all patients. Some patients with COPD exacerbations have a favorable physiologic response to heliox therapy, whereas others do not, and predicting who will be a responder and who will not is difficult.
B. Incorrect response: See explanation A.
C. Incorrect response: See explanation A.
D. Incorrect response: See explanation A.

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